GeneTex
United States (US)

FBXO11 antibody

GTX54008_20180530_ICCIF_18121410_138.jpg
GTX54008_20180530_WB_18121410_681.jpg

Cat No. GTX54008

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:20 - 1:100
Not tested in other applications.

Calculated MW

104 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant funsion protein containing a sequence corresponding to amino acids 688-927 of human FBXO11 (NP_001177203.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

FBX11 Antibody , PRMT9 Antibody , UG063H01 Antibody , UBR6 Antibody , VIT1 Antibody

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis

Database

DATA IMAGES
GTX54008_20180530_ICCIF_18121410_138.jpg

GTX54008 ICC/IF Image

ICC/IF analysis of MCF-7 cell using GTX54008 FBXO11 antibody.
Blue : DAPI

GTX54008_20180530_WB_18121410_681.jpg

GTX54008 WB Image

WB analysis of various samples using GTX54008 FBXO11 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Package List Price ($)
$ 319