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FDPS antibody [N1C3]

Anti-FDPS antibody [N1C3] used in Western Blot (WB). GTX105301
Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301
Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301
Anti-FDPS antibody [N1C3] used in Western Blot (WB). GTX105301
Anti-FDPS antibody [N1C3] used in Western Blot (WB). GTX105301
Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301
Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301
Anti-FDPS antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX105301
Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301

Cat. No. GTX105301

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all FDPS products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Positive Control

Mouse brain , rat liver

Predict Reactivity

Bovine, Pig(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.35 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human FDPS. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_10615664

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

farnesyl diphosphate synthase , FPPS , FPS , POROK9

Cellular Localization

Cytoplasm

Background

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Database

Research Area

DATA IMAGES

Anti-FDPS antibody [N1C3] used in Western Blot (WB). GTX105301

GTX105301 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with FDPS antibody [N1C3] (GTX105301) diluted at 1:3000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301

GTX105301 IHC-P Image

FDPS antibody [N1C3] detects FDPS protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded rat kidney.
FDPS stained by FDPS antibody [N1C3] (GTX105301) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301

GTX105301 IHC-P Image

FDPS antibody [N1C3] detects FDPS protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse kidney.
FDPS stained by FDPS antibody [N1C3] (GTX105301) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-FDPS antibody [N1C3] used in Western Blot (WB). GTX105301

GTX105301 WB Image

FDPS antibody detects FDPS protein by western blot analysis.
A. 50 μg rat liver lysate/extract
10% SDS-PAGE
FDPS antibody (GTX105301) dilution: 1:5000
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-FDPS antibody [N1C3] used in Western Blot (WB). GTX105301

GTX105301 WB Image

Sample (50 μg of whole cell lysate)
A: mouse brain
10% SDS PAGE
GTX105301 diluted at 1:3000
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301

GTX105301 IHC-P Image

FDPS antibody [N1C3] detects FDPS protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded rat kidney.
FDPS stained by FDPS antibody [N1C3] (GTX105301) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301

GTX105301 IHC-P Image

FDPS antibody [N1C3] detects FDPS protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse kidney.
FDPS stained by FDPS antibody [N1C3] (GTX105301) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-FDPS antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX105301

GTX105301 ICC/IF Image

FDPS antibody [N1C3] detects FDPS protein at cytoplasm by immunofluorescent analysis.
Sample: HeLa cells were fixed in ice-cold MeOH for 5 min.
Green: FDPS stained by FDPS antibody [N1C3] (GTX105301) diluted at 1:500.

Anti-FDPS antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX105301

GTX105301 IHC-P Image

FDPS antibody [N1C3] detects secreted FDPS protein by immunohistochemical analysis.
Sample: Paraffin-embedded rat pancreas.
FDPS stained by FDPS antibody [N1C3] (GTX105301) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

Application Reference

Wang SA et al. Mol Oncol 2023; NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells
Application : WB
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 399
$ 169