GeneTex
United States (US)

FE65 antibody

GTX30053_20180530_WB_18121410_271.jpg
GTX30053_20180530_IHC-P_18121410_592.jpg
GTX30053_20180530_ICCIF_18121410_404.jpg

Cat No. GTX30053

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

77 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Amyloid Beta Precursor Protein Binding Family B Member 1,Fe65,Mgc:9072,Rir,Apbb1

Background

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Database

Research Area

DATA IMAGES
GTX30053_20180530_WB_18121410_271.jpg

GTX30053 WB Image

WB analysis of various samples using GTX30053 FE65 antibody.
Dilution : 1:1000
Loading : 25μg per lane

GTX30053_20180530_IHC-P_18121410_592.jpg

GTX30053 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX30053 FE65 antibody.
Dilution : 1:100

GTX30053_20180530_ICCIF_18121410_404.jpg

GTX30053 ICC/IF Image

ICC/IF analysis of U2OS cell using GTX30053 FE65 antibody.
Blue : DAPI

Package List Price ($)
$ 319