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FE65 antibody

Anti-FE65 antibody used in Western Blot (WB). GTX30053
Anti-FE65 antibody used in IHC (Paraffin sections) (IHC-P). GTX30053
Anti-FE65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX30053

Cat. No. GTX30053

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all FE65 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:50 - 1:200
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

77 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

amyloid beta precursor protein binding family B member 1 , FE65 , MGC:9072 , RIR

Cellular Localization

Cell membrane,Cytoplasm,Nucleus,Nucleus speckle

Background

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Database

Research Area

DATA IMAGES

Anti-FE65 antibody used in Western Blot (WB). GTX30053

GTX30053 WB Image

WB analysis of various sample lysates using GTX30053 FE65 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-FE65 antibody used in IHC (Paraffin sections) (IHC-P). GTX30053

GTX30053 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX30053 FE65 antibody.
Dilution : 1:100

Anti-FE65 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX30053

GTX30053 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX30053 FE65 antibody.
Blue : DAPI

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399