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FGFR1 antibody, C-term

Anti-FGFR1 antibody, C-term used in Western Blot (WB). GTX89588
Anti-FGFR1 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89588
Anti-FGFR1 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89588

Cat. No. GTX89588

Host

Goat

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($399)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.3-1μg/ml
IHC-P 4μg/ml

Note :

IHC-P
Human Small Intestine shows staining of the enterocytic cytoplasm.

Not tested in other applications.

Calculated MW

92 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX89588-PEP).

Product Note

This antibody is expected to recognise five isoforms (as represented by NP_075598.2; NP_056934.2; NP_075593.1; NP_075594.1; NP_075599.1).

Predict Reactivity

Bovine, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

TBS pH7.3, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence CLPRHPAQLANGGLKR, from the C Terminus of the protein sequence according to NP_075598.2; NP_056934.2; NP_075593.1; NP_075594.1; NP_075599.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

fibroblast growth factor receptor 1 , BFGFR , CD331 , CEK , ECCL , FGFBR , FGFR-1 , FLG , FLT-2 , FLT2 , HBGFR , HH2 , HRTFDS , KAL2 , N-SAM , OGD , bFGF-R-1

Cellular Localization

Cell membrane; Single-pass type I membrane protein , Nucleus , Cytoplasm, cytosol , Cytoplasmic vesicle

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-FGFR1 antibody, C-term used in Western Blot (WB). GTX89588

GTX89588 WB Image

WB analysis of human breast lysate using GTX89588 FGFR1 antibody, C-term.
Dilution : 0.3μg/ml
Loading : 35μg protein in RIPA buffer

Anti-FGFR1 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89588

GTX89588 IHC-P Image

IHC-P analysis of human small intestine using GTX89588 FGFR1 antibody, C-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 4μg/ml

Anti-FGFR1 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89588

GTX89588 IHC-P Image

IHC-P analysis of human kidney using GTX89588 FGFR1 antibody, C-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 4μg/ml

REFERENCE

There are currently no references for FGFR1 antibody, C-term (GTX89588). Be the first to share your publications with this product.

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399