GeneTex
United States (US)

FGFR3 antibody

Anti-FGFR3 antibody used in IHC (Paraffin sections) (IHC-P). GTX31549
Anti-FGFR3 antibody used in IHC (Paraffin sections) (IHC-P). GTX31549
Anti-FGFR3 antibody used in Western Blot (WB). GTX31549

Cat No. GTX31549

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

88 kDa. ( Note )

Positive Control

SK-N-SH Cell Lysate(GTX23956)

Specificity/Sensitivity

At least three isoforms of FGFR3 are known to exist; this antibody will detect all three.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.The immunogen is located within amino acids 630 - 680 of FGFR3.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Fibroblast Growth Factor Receptor 3,Ach,Cd333,Cek2,Hsfgfr3Ex,Jtk4,Fgfr3

Background

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]

Database

Research Area

DATA IMAGES
Anti-FGFR3 antibody used in IHC (Paraffin sections) (IHC-P). GTX31549

GTX31549 IHC-P Image

IHC-P analysis of rat brain tissue using GTX31549 FGFR3 antibody.
Working concentration : 20 μg/ml

Anti-FGFR3 antibody used in IHC (Paraffin sections) (IHC-P). GTX31549

GTX31549 IHC-P Image

IHC-P analysis of rat brain tissue using GTX31549 FGFR3 antibody.
Working concentration : 2.5 μg/ml

Anti-FGFR3 antibody used in Western Blot (WB). GTX31549

GTX31549 WB Image

WB analysis of SK-N-SH cell lysate using GTX31549 FGFR3 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

Package List Price ($)
$ 339