GeneTex

  • Country / Location Selection

United States (US)

FIP1L1 antibody

Anti-FIP1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55623
Anti-FIP1L1 antibody used in Western Blot (WB). GTX55623
Anti-FIP1L1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55623
Anti-FIP1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55623
Anti-FIP1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55623

Cat. No. GTX55623

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all FIP1L1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:100
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

67 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

factor interacting with PAPOLA and CPSF1 , FIP1 , Rhe , hFip1

Cellular Localization

Nucleus

Background

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Database

DATA IMAGES

Anti-FIP1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55623

GTX55623 IHC-P Image

IHC-P analysis of mouse pancreas tissue using GTX55623 FIP1L1 antibody.
Dilution : 1:100

Anti-FIP1L1 antibody used in Western Blot (WB). GTX55623

GTX55623 WB Image

WB analysis of various sample lysates using GTX55623 FIP1L1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-FIP1L1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55623

GTX55623 ICC/IF Image

ICC/IF analysis of A549 cells using GTX55623 FIP1L1 antibody.

Anti-FIP1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55623

GTX55623 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX55623 FIP1L1 antibody.
Dilution : 1:100

Anti-FIP1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX55623

GTX55623 IHC-P Image

IHC-P analysis of rat testis tissue using GTX55623 FIP1L1 antibody.
Dilution : 1:100

REFERENCE

There are currently no references for FIP1L1 antibody (GTX55623). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for FIP1L1 antibody (GTX55623). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399