APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
A-431 Cell Slide(GTX25525) , A431 Cell Lysate(GTX27909)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
FKBP12 antibody was raised against an 18 amino acid peptide near the center of human FKBP12.The immunogen is located within the first 50 amino acids of FKBP12.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
FKBP prolyl isomerase 1A , FKBP-12 , FKBP-1A , FKBP1 , FKBP12 , PKC12 , PKCI2 , PPIASE
Cellular Localization
Cytoplasm, cytosol
Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
Database
Research Area
DATA IMAGES
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GTX31576 ICC/IF Image
ICC/IF analysis of A431 cells using GTX31576 FKBP12 antibody.
Working concentration : 20 μg/ml
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GTX31576 WB Image
WB analysis of A431 cell lysate using GTX31576 FKBP12 antibody.
Working concentration : 1 μg/ml
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GTX31576 ICC/IF Image
ICC/IF analysis of A431 cells using GTX31576 FKBP12 antibody.
Working concentration : 5 μg/ml
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REFERENCE
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REVIEW
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