APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.01-0.03μg/ml |
3.75μg/ml |
Not tested in other applications.
Calculated MW
Positive Control
The peptide used to generate this antibody is available for purchase (GTX88487-PEP).
PROPERTIES
Form
Liquid
Buffer
TBS, 0.5% BSA
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Peptide with sequence C-DHPTDTEMKEEQKSN, from the C Terminus of the protein sequence according to NP_002005.1.
Purification
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
FKBP prolyl isomerase 4 , FKBP51 , FKBP52 , FKBP59 , HBI , Hsp56 , PPIase , p52
Cellular Localization
Cytoplasm, cytosol , Mitochondrion , Nucleus , Cytoplasm, cytoskeleton
Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Database
Research Area
DATA IMAGES
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GTX88487 IHC-P Image
IHC-P analysis of human cerebellum using GTX88487 FKBP4 antibody, C-term. Antigen retrieval : citrate buffer pH 6 Dilution : 3.75μg/ml
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GTX88487 IHC-P Image
IHC-P analysis of human kidney using GTX88487 FKBP4 antibody, C-term. Antigen retrieval : citrate buffer pH 6 Dilution : 3.75μg/ml
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GTX88487 WB Image
WB analysis of human placenta lysate using GTX88487 FKBP4 antibody, C-term. Dilution : 0.01μg/ml Loading : 35μg protein in RIPA buffer
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REFERENCE
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REVIEW
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