Western blot at1:500 to 1:1000 dilution.
Recognizes all FLIP splice variants including FLIP alpha, beta, gamma, and delta.
PBS with 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
0.5mg/ml(Please refer to the vial label for the specific concentration.)
Peptide corresponding to amino acids 2 to 18 of human FLIP2. The sequence is identical in all FLIP splice variants.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Q01543, SIC1, SIC-1, FLI1, FLIP, EWSR2, 2313, 193067, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, SIC 1, c FLIP, FLAME 1, I FLICE, c FLIPL, c FLIPR, c FLIPS, cFLIP, IFLICE, cFLIPL, cFLIPR, cFLIPS
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively (1,2). The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP (3-7). FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and-10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPa, b, g, and d, respectively (8).