FLIP peptide

Cat No. GTX28458

Application	Blocking
Species	Human

See all FLIP products;

Datasheet

APPLICATION

Application Note

The peptide is used for blocking the activity of FLIPs (GTX28423). Incubatingthe peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks theantibody activity in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2 with 10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl, 0.1% bovine serum albumin, and 0.02% sodium azide

Storage

Store the peptide at -20˚C, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Casp8 And Fadd Like Apoptosis Regulator,Cash,Casp8Ap1,Clarp,Casper,Flame,Flame-1,Flame1,Flip,I-Flice,Mrit,C-Flip,C-Flipl,C-Flipr,C-Flips,Cflar

Background

The human homolog of viral FLIP has four splice variants known as FLIP alpha, Beta, gamma and kappa. These are FLICE inhibitory proteins also known as Casper, I-FLICE, FLAME-1, CASH, CLARP and Usurpin. They contain two death effector domains and one caspase domain. FLIP interacts with FADD, caspase-8 and 10 to inhibit apoptosis initiated by Fas, TNF-R1 and TRAIL-R.