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FLT3 antibody

Anti-FLT3 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50518
Anti-FLT3 antibody used in Western Blot (WB). GTX50518

Cat No. GTX50518

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:1000
ICC/IF 1:100-1:200
Not tested in other applications.

Calculated MW

113 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from human FLT3.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

fms related tyrosine kinase 3 , CD135 , FLK-2 , FLK2 , STK1

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

Database

Research Area

DATA IMAGES

Anti-FLT3 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50518

GTX50518 ICC/IF Image

ICC/IF analysis of methanol-fixed HeLa cells using GTX50518 FLT3 antibody.

Anti-FLT3 antibody used in Western Blot (WB). GTX50518

GTX50518 WB Image

WB analysis of extracts from 293 and MCF cells using GTX50518 FLT3 antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319