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FLT3 (phospho Tyr969) antibody [T.602.6]

Orthogonal
Anti-FLT3 (phospho Tyr969) antibody [T.602.6] used in Western Blot (WB). GTX36299

Cat. No. GTX36299

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 T.602.6

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse
Package
50 μl ($399)
See all FLT3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
Not tested in other applications.

Calculated MW

113 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.01M HEPES pH7.5, 0.15M NaCl, 100μg/ml BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic phosphopeptide corresponding to the sequence surrounding pTyr969 of human FLT3

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

fms related tyrosine kinase 3 , CD135 , FLK-2 , FLK2 , STK1

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

Database

Research Area

DATA IMAGES

Anti-FLT3 (phospho Tyr969) antibody [T.602.6] used in Western Blot (WB). GTX36299

GTX36299 WB Image

Orthogonal

WB analysis of Baf3 cells untreated or treated with FLT3 ligand using GTX36299 FLT3 (phospho Tyr969) antibody [T.602.6] (upper panel) or FLT3 antibody (lower panel).

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399