GeneTex
United States (US)

FLT3 (phospho Tyr969) antibody [T.602.6]

GTX36299_1857_WB_19011519_138.jpg

Cat No. GTX36299

Host Rabbit
Clonality Monoclonal
Clone Name T.602.6
Isotype IgG
Application WB
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000
Not tested in other applications.

Calculated MW

113 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.01M HEPES pH 7.5, 0.15M NaCl, 100μg/ml BSA, 50% glycerol, <0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic phosphopeptide corresponding to the sequence surrounding pTyr969 of human FLT3

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Fms Related Tyrosine Kinase 3,Cd135,Flk-2,Flk2,Stk1,Flt3

Cellular Localization

Endoplasmic reticulum lumen,Membrane

Background

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

Database

Research Area

DATA IMAGES
GTX36299_1857_WB_19011519_138.jpg

GTX36299 WB Image

WB analysis of Baf3 cells untreated or treated with FLT3 ligand using GTX36299 FLT3 (phospho Tyr969) antibody [T.602.6] (upper panel) or FLT3 antibody (lower panel).

Package List Price ($)
$ 319