GeneTex
  • Country / Location Selection

United States (US)

FMO3 antibody

Anti-FMO3 antibody used in Western Blot (WB). GTX55626
Anti-FMO3 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55626

Cat No. GTX55626

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF

Reactivity

Human, Mouse
Package
100 μl ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:10 - 1:100
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3 (NP_001002294.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

flavin containing monooxygenase 3 , FMOII , TMAU , dJ127D3.1

Cellular Localization

Endoplasmic reticulum membrane

Background

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-FMO3 antibody used in Western Blot (WB). GTX55626

GTX55626 WB Image

WB analysis of mouse liver tissue lysate using GTX55626 FMO3 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-FMO3 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55626

GTX55626 ICC/IF Image

ICC/IF analysis of A549 cells using GTX55626 FMO3 antibody.
Blue : DAPI

REFERENCE

There are currently no references for FMO3 antibody (GTX55626). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for FMO3 antibody (GTX55626). Be the first to share your experience with this product.
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339