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FOXO1 antibody [4E7]

Anti-FOXO1 antibody [4E7] used in Immunohistochemistry (IHC). GTX70189

Cat No. GTX70189

Host

Mouse

Clonality

Monoclonal

Clone Name

4E7

Isotype

IgG1

Application

WB, IHC

Reactivity

Human
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.1 - 2 μg/ml
IHC Assay dependent
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Positive Control

Cos 1 cells transfected with human FKHR

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing no preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Amino acids 242-655 of FKHR expressed in E. coli.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Forkhead Box O1 , Fkh1 , Fkhr , Foxo1A , Foxo1

Background

FKHR-7H3 recognizes FKHR (ForKHead in Rhabdomyosarcoma), a 70a protein, which is a member of the forkhead homeotic gene family of transcription factors (FKH/HNF-3). Members of the forkhead family can be classified and grouped by their degree of homology within the 100-120aa region that is necessary and sufficient for DNA binding and binding-site specificity. The FKHR subfamily of forkhead proteins is relatively divergent from the other members of the forkhead transcription factor family. With all members in this subfamily containing a signature insertion of 5 amino acids next to the helix 3 in the middle of the forkhead domain, and lack the well conserved amino terminal KPPY sequence found in most forkhead genes. Recently, it has been shown that members of the FKHR gene family are phosphorylated by Akt and this phosphorylation regulates its cellular localization promoting cell survival.

Database

Research Area

DATA IMAGES

Anti-FOXO1 antibody [4E7] used in Immunohistochemistry (IHC). GTX70189

GTX70189 IHC Image

REFERENCE

There are currently no references for FOXO1 antibody [4E7] (GTX70189). Be the first to share your publications with this product.

REVIEW

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Package List Price ($)
$ 329