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FPRL1 antibody

Orthogonal
Anti-FPRL1 antibody used in Western Blot (WB). GTX130627
Anti-FPRL1 antibody used in Western Blot (WB). GTX130627

Cat. No. GTX130627

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all FPRL1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

39 kDa. ( Note )

Positive Control

HL-60 membrane extracts

Predict Reactivity

Mouse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.95 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide encompassing a sequence within the Extracellular domain of human FPRL1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2886307

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

formyl peptide receptor 2 , ALXR , FMLP-R-II , FMLPX , FPR2A , FPRH1 , FPRH2 , FPRL1 , HM63 , LXA4R

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Database

Research Area

DATA IMAGES

Anti-FPRL1 antibody used in Western Blot (WB). GTX130627

GTX130627 WB Image

Orthogonal

FPRL1 antibody detects FPRL1 protein by western blot analysis. HL-60 whole cell extracts and membrane extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with FPRL1 antibody (GTX130627) at a dilution of 1:1000 and developed with Trident femto Western HRP Substrate (GTX14698).

Anti-FPRL1 antibody used in Western Blot (WB). GTX130627

GTX130627 WB Image

Orthogonal

The data was published in the journal Mol Oncol in 2018. PMID: 29603594

REFERENCE

Application Reference

Lin CY et al. Mol Oncol 2018; 12 (5) : 756-771 Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression.
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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 399
$ 169