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FSH Receptor antibody [FSHR/1400]

Anti-FSH Receptor antibody [FSHR/1400] used in IHC (Paraffin sections) (IHC-P). GTX34745

Cat No. GTX34745

Host Mouse
Clonality Monoclonal
Clone Name FSHR/1400
Isotype IgG1
Application IHC-P
Reactivity Human
Package
100 μg ($429)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 0.1-0.2ug/ml for 30 min at RT
Not tested in other applications.

Calculated MW

78 kDa. ( Note )

Specificity/Sensitivity

Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human full-length FSHR protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Follicle Stimulating Hormone Receptor , Fshr1 , Fshro , Lgr1 , Odg1 , Fshr

Background

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Database

Research Area

DATA IMAGES
Anti-FSH Receptor antibody [FSHR/1400] used in IHC (Paraffin sections) (IHC-P). GTX34745

GTX34745 IHC-P Image

Formalin-fixed, paraffin-embedded human Uterine Carcinoma stained with FSH Receptor Monoclonal Antibody (FSHR/1400).

REFERENCE
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REVIEW
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Package List Price ($)
$ 429