APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Assay dependent |
1/500-1/4,000 |
Assay dependent |
Note :
Neutralizing/Inhibition
Mouse anti Human Complement Factor I antibody, clone 3R/8 blocks function of complement factor I.
|
Not tested in other applications.
Calculated MW
Product Note
This antibody recognizes complement factor I. Clone 3R/8 blocks function of complement factor I.
PROPERTIES
Form
Liquid
Buffer
Borate buffered saline
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Native human factor I from serum.
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
complement factor I , AHUS3 , ARMD13 , C3BINA , C3b-INA , FI , IF , KAF
Cellular Localization
Secreted
Background
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
Database
Research Area
REFERENCE
There are currently no references for Factor I antibody [3R/8] (GTX41627). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Factor I antibody [3R/8] (GTX41627). Be the first to share your experience with this product.