GeneTex
  • Country / Location Selection

United States (US)

Factor I antibody

Anti-Factor I antibody used in Western Blot (WB). GTX32531
Anti-Factor I antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32531

Cat No. GTX32531

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF

Reactivity

Human, Mouse
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:100
Not tested in other applications.

Calculated MW

66 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human CFI (NP_000195.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

complement factor I , AHUS3 , ARMD13 , C3BINA , C3b-INA , FI , IF , KAF

Cellular Localization

Secreted

Background

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]

Database

Research Area

DATA IMAGES

Anti-Factor I antibody used in Western Blot (WB). GTX32531

GTX32531 WB Image

WB analysis of various samples using GTX32531 Factor I antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Factor I antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32531

GTX32531 ICC/IF Image

ICC/IF analysis of HeLa cell using GTX32531 Factor I antibody.
Blue : DAPI

REFERENCE

There are currently no references for Factor I antibody (GTX32531). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Factor I antibody (GTX32531). Be the first to share your experience with this product.