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Factor V Heavy chain antibody [B10]

Cat. No. GTX21015

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 B10

Isotype

 IgG1

Application

 WB, ELISA, IHC

Reactivity

 Human
Package
125 μg ($399)
See all Factor V products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

252 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human Factor V.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

F5 , FVL , PCCF , RPRGL1 , THPH2 , coagulation factor V

Cellular Localization

Secreted

Background

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

Database

Research Area

REFERENCE

Application Reference

Meyer AD et al. J Thromb Haemost 2020; 18 (2) : 399-410 Effect of blood flow on platelets, leukocytes, and extracellular vesicles in thrombosis of simulated neonatal extracorporeal circulation.

Clone Reference

A M Gewirtz et al. Blood. 1986; 67 (6) Biology of human megakaryocyte factor V
Application : WB
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SDS
PBS.pdf
Package List Price ($)
$ 399