GeneTex

  • Country / Location Selection

United States (US)

Factor VIII antibody [RFF-VIIIC/8]

Anti-Factor VIII antibody [RFF-VIIIC/8] used in ELISA (ELISA). GTX41178

Cat. No. GTX41178

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 RFF-VIIIC/8

Isotype

 IgG1

Application

 WB, ELISA, RIA

Reactivity

 Human, Pig
Package
500 μg ($589)
See all Factor VIII products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA 1/500-1/5,000
RIA Assay dependent
Not tested in other applications.

Calculated MW

267 kDa. ( Note )

Product Note

This antibody recognizes an epitope towards the N-terminus of full-length Factor VIII. It also recognizes the 210kDa, 90kDa and 40kDa cleavage products. Clone RFF-VIIIC/8 does not cross-react with von Willebrand factor.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Affinity purified human Factor VIII.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

coagulation factor VIII , AHF , DXS1253E , F8B , F8C , FVIII , HEMA

Background

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Factor VIII antibody [RFF-VIIIC/8] used in ELISA (ELISA). GTX41178

GTX41178 ELISA Image

ELISA analysis of Factor VIII recombinant protein using GTX41178 Factor VIII antibody [RFF-VIIIC/8].

REFERENCE

There are currently no references for Factor VIII antibody [RFF-VIIIC/8] (GTX41178). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Factor VIII antibody [RFF-VIIIC/8] (GTX41178). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 589