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Factor XIIIa antibody [MSVA-813R] HistoMAX™

Recombinant antibody HistoMAX
Anti-Factor XIIIa antibody [MSVA-813R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04452
Anti-Factor XIIIa antibody [MSVA-813R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04452
Anti-Factor XIIIa antibody [MSVA-813R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04452

Cat. No. GTX04452

Host

Rabbit

Clonality

Monoclonal

Clone Name

MSVA-813R

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
500 μl ($679),
100 μl ($299)
PRODUCT

Summary

This antibody was validated on 76 different Normal Tissues by IHC-P.

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.

This antibody has been validated by Autostainer including Agilent/Dako - Autostainer Link 48, Bond RX-Lecia, and Roche-Ventana Discovery ULTRA. The detailed steps by Autostainer please refer to the protocol.

Not tested in other applications.

Calculated MW

83 kDa. ( Note )

Positive Control

Colon: A fraction of monocytic cells in the mucosa should show a strong cytoplasmic factor XIIIa immunostaining.

Negative Control

Colon: Factor XIIIa immunostaining should be absent in epithelial, endothelial and smooth muscle cells.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA (Please contact us for PBS only format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human Factor XIIIa protein (aa46-181)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

coagulation factor XIII A chain , F13A

Cellular Localization

Cytoplasm , Secreted

Background

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Factor XIIIa antibody [MSVA-813R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04452

GTX04452 IHC-P Image

IHC-P analysis of human Hodgkin's lymphoma tissue section using GTX04452 Factor XIIIa antibody [MSVA-813R] HistoMAX.
Hodgkin's lymphoma containing a dense population of Factor XIIIa positive cells.

Anti-Factor XIIIa antibody [MSVA-813R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04452

GTX04452 IHC-P Image

IHC-P analysis of human appendix mucosa tissue section using GTX04452 Factor XIIIa antibody [MSVA-813R] HistoMAX™.
A fraction of monocytic cells in appendix mucosa shows a strong cytoplasmic Factor XIIIa immunostaining.

Anti-Factor XIIIa antibody [MSVA-813R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04452

GTX04452 IHC-P Image

IHC-P analysis of human lymph node tissue section using GTX04452 Factor XIIIa antibody [MSVA-813R] HistoMAX™.
Strong Factor XIIIa immunostaining of sinus histiocytes in a lymph node.

REFERENCE

There are currently no references for Factor XIIIa antibody [MSVA-813R] HistoMAX™ (GTX04452). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Factor XIIIa antibody [MSVA-813R] HistoMAX™ (GTX04452). Be the first to share your experience with this product.
Package List Price ($)
$ 679
$ 299