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Fas antibody [APO-1-3] (Azide free)

Cat No. GTX33923

Host

Mouse

Clonality

Monoclonal

Clone Name

APO-1-3

Isotype

IgG3

Application

WB, FACS, IP, Functional Assay

Reactivity

Human
Package
50 μg ($319)

APPLICATION

Application Note

Functional Assay: Induces apoptosis with or without cross-linking (Protein A), depending on cell type. Note: Optimal conditions must be determined.

Calculated MW

38 kDa. ( Note )

Specificity/Sensitivity

Recognizes human Fas.

PROPERTIES

Form

Liquid

Buffer

PBS.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human Fas.

Purity

≧95% (SDS-PAGE)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Fas Cell Surface Death Receptor , Alps1A , Apo-1 , Apt1 , Cd95 , Fas1 , Fastm , Tnfrsf6 , Fas

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Database

Research Area

REFERENCE

REVIEW

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Package List Price ($)
$ 319