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Fas antibody [UT-1] (Azide Free)

Anti-Fas antibody [UT-1] (Azide Free) used in Activation/Stimulation/Induction (Activation). GTX11881

Cat No. GTX11881

Host

Mouse

Clonality

Monoclonal

Clone Name

UT-1

Isotype

IgM

Application

FACS, Functional Assay, Activation

Reactivity

Human
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS Assay dependent
Functional Assay Assay dependent
Activation Assay dependent
Not tested in other applications.

Calculated MW

38 kDa. ( Note )

Product Note

This antibody UT-1 does excellently induce Fas mediated apoptosis, similarly as CH11 antibody.

PROPERTIES

Form

Liquid

Buffer

HEPES buffered saline (HBS) solution, 0.2 μm filter sterilized

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

HUT-78 human T cell lymphoma cells

Purification

Purified by precipitation and chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ALPS1A , APO1 , APT1 , CD95 , FAS , FAS1 , FASTM , Fas cell surface death receptor , TNFRSF6 , Fas

Cellular Localization

Cell membrane,Secreted

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Database

Research Area

DATA IMAGES

Anti-Fas antibody [UT-1] (Azide Free) used in Activation/Stimulation/Induction (Activation). GTX11881

GTX11881 Activation Image

Induction of apoptosis in various hematopoetic cell lines by use of anti-Fas antibodies. Induction of apoptosis was measured by Apoptosis Assay Kit - FITC.
Red (full) : Untreated control cells
Black : positive control anti-Fas antibody
Green : GTX11881
Panel A : Jurkat cells
Panel B : TF-1 cells
Panel C : CEM cells
Panel D : MOLT-4 cells

REFERENCE

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REVIEW

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Package List Price ($)
$ 339