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Fc epsilon R1 alpha antibody [MAR-1] (APC)

Anti-Fc epsilon R1 alpha antibody [MAR-1] (APC) used in Flow cytometry (FACS). GTX01480-07

Cat. No. GTX01480-07

Reference 3

Host

 Armenian Hamster

Clonality

 Monoclonal

Clone Name

 MAR-1

Isotype

 IgG

Application

 FACS

Reactivity

 Mouse
Package
100 μg ($339)
See all Fc epsilon R1 alpha products
PRODUCT

Summary

The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro / in vivo.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

30 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Allophycocyanin (APC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Fc fragment of IgE receptor Ia , FCE1A , FCER1A , FcERI , Fc epsilon R1 alpha

Cellular Localization

Cell membrane

Background

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

Database

Research Area

DATA IMAGES

Anti-Fc epsilon R1 alpha antibody [MAR-1] (APC) used in Flow cytometry (FACS). GTX01480-07

GTX01480-07 FACS Image

FACS analysis of MC/9 cells using GTX01480-07 Fc epsilon R1 alpha antibody [MAR-1] (APC).
Solid lone : primary antibody
Dashed line : isotype control
antibody amount : 0.125 μg (5 μl)

REFERENCE

Clone Reference

2012; Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.
2012; Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion.
2012; Critical role of P1-Runx1 in mouse basophil development.
Submit a Reference

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 339