APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Specificity/Sensitivity
fibrinogen and fibrin degradation products.
PROPERTIES
Form
Liquid
Buffer
PBS pH 7.4, 0.09 % sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Fibrin degradation products.
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
FGA, Fib2, fibrinogen alpha chain
Cellular Localization
Secreted
Background
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]
Database
DATA IMAGES
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GTX10066 WB Image
Detection of fibrinogen by fibrinogen antibodies in Western blotting (non-reducing conditions). Lane 1: Fibrinogen antibody [1F3] (GTX10066); Lane 2: Fibrinogen antibody [15H12] (GTX10065)
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