GeneTex
United States (US)

Filaggrin antibody

Cat No. GTX37695

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:100-500
IHC-P 1:100-500 (based on 0.5 mg/ml)
Not tested in other applications.

Calculated MW

435 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

10 mM PBS, 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5mg/ml

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human Filaggrin. Please contact us for the exact immunogen sequence.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ATOD2

Cellular Localization

Cytoplasmic granule

Background

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
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Database

Research Area

Reference