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Filamin A antibody [N2], N-term

Orthogonal
Anti-Filamin A antibody [N2], N-term used in Western Blot (WB). GTX109931
Anti-Filamin A antibody [N2], N-term used in Western Blot (WB). GTX109931

Cat. No. GTX109931

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all Filamin A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

281 kDa. ( Note )

Positive Control

A431

Predict Reactivity

Mouse, Rat, Rabbit, Bovine(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human Filamin A. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11164611

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

filamin A , ABP-280 , ABPX , CSBS , CVD1 , FGS2 , FLN , FLN-A , FLN1 , FMD , MNS , NHBP , OPD , OPD1 , OPD2 , XLVD , XMVD

Cellular Localization

Cytoplasm , cell cortex , cytoskeleton

Background

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Database

Research Area

DATA IMAGES

Anti-Filamin A antibody [N2], N-term used in Western Blot (WB). GTX109931

GTX109931 WB Image

Sample (30 ug of whole cell lysate)
A: A431
5% SDS PAGE
GTX109931 diluted at 1:1000

Anti-Filamin A antibody [N2], N-term used in Western Blot (WB). GTX109931

GTX109931 WB Image

Orthogonal

The data was published in the 2018 in Sci Rep. PMID: 29891991

REFERENCE

Application Reference

Brzozowski JS et al. Sci Rep 2018; 8 (1) : 8822 Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169