GeneTex
United States (US)

Filamin A (phospho Ser2152) antibody

GTX32328_20190131_WB_19013102_821.jpg
GTX32328_20190131_IHC-P_19013102_872.jpg

Cat No. GTX32328

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

281 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of Filamin A. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Filamin A,Abp-280,Abpx,Csbs,Cvd1,Fgs2,Fln,Fln-A,Fln1,Fmd,Mns,Nhbp,Opd,Opd1,Opd2,Xlvd,Xmvd,Flna

Cellular Localization

Cell cortex,Cytoplasm,Cytoskeleton

Background

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Database

Research Area

DATA IMAGES
GTX32328_20190131_WB_19013102_821.jpg

GTX32328 WB Image

WB analysis of calyculin A-treated HeLa (A), EGF-treated A431 (B) whole cell lysates using GTX32328 Filamin A (phospho Ser2152) antibody.

GTX32328_20190131_IHC-P_19013102_872.jpg

GTX32328 IHC-P Image

IHC-P analysis of formalin fixed human lung cancer tissue section using GTX32328 Filamin A (phospho Ser2152) antibody.
Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

Package List Price ($)
$ 319