APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 3 - 6 μg/ml |
| 6 - 14 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Mouse, Rat, Rabbit, Bovine, Dog, Chicken, Pig, Bat, Elephant, Gibbon, Gorilla, Horse, Lizard, Marmoset, Opossum, Orangutan, Panda, Turkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human Frizzled-6.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375791
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
frizzled class receptor 6 , FZ6 , FZD6 , HFZ6 , NDNC10 , Frizzled 6
Cellular Localization
Membrane,Cell membrane,Cell surface,Apical cell membrane,Cytoplasmic vesicle membrane
Background
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Database
Research Area
DATA IMAGES
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GTX71523 IHC-P Image
IHC-P analysis of human lung, non-small cell carcinoma tissue using GTX71523 Frizzled 6 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX71523 ICC/IF Image
ICC/IF analysis of HEK293 transfected with Frizzled 6 using GTX71523 Frizzled 6 antibody.
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GTX71523 IHC-P Image
IHC-P analysis of human pancreas tissue using GTX71523 Frizzled 6 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX71523 IHC-P Image
IHC-P analysis of human skin, melanoma tissue using GTX71523 Frizzled 6 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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REFERENCE
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REVIEW
There are currently no reviews for Frizzled 6 antibody (GTX71523). Be the first to share your experience with this product.
