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GABA A Receptor alpha 2 antibody

Anti-GABA A Receptor alpha 2 antibody used in Western Blot (WB). GTX48611

Cat No. GTX48611

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human, Mouse, Rat, Zebrafish, Bovine, Dog, Primate
Package
50 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000
Not tested in other applications.

Calculated MW

51 kDa. ( Note )

Specificity/Sensitivity

Specific for the ~51k alpha 2-subunit of the GABAA receptor in Western blots. Labeling is absent in alpha 2-subunit knockout animals.

PROPERTIES

Form

Liquid

Buffer

10mM HEPES pH 7.5, 0.15M NaCl, 0.1 mg/ml BSA, 50% Glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Fusion protein from the cytoplasmic loop of the alpha 2 subunit of rat GABA A receptor.

Purification

Purified by ion exchange chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

gamma-aminobutyric acid type A receptor alpha2 subunit

Cellular Localization

Cell membrane,Cell projection, dendrite

Background

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-GABA A Receptor alpha 2 antibody used in Western Blot (WB). GTX48611

GTX48611 WB Image

WB analysis of wild type (control) and GABA A Receptor alpha 2 knockout (a2-K/O) rat brain tissue lysate using GTX48611 GABA A Receptor alpha 2 antibody.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf