*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Specific for the ~51k alpha 2-subunit of the GABAA receptor in Western blots. Labeling is absent in alpha 2-subunit knockout animals.
10mM HEPES pH 7.5, 0.15M NaCl, 0.1 mg/ml BSA, 50% Glycerol
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
Fusion protein from the cytoplasmic loop of the alpha 2 subunit of rat GABA A receptor.
Purified by ion exchange chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
gamma-aminobutyric acid type A receptor alpha2 subunit
Cell membrane,Cell projection, dendrite
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]