100 μl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50% glycerol.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 conjugated to KLH
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
dJ271M21.1.1, gammaaminobutyric acid (GABA) B receptor, 1, GABBR13, GABA B Receptor1, dJ271M21.1.2, GPRC3A, GABBR1, GB1, GABBR1-3, GABABR1, FLJ92613, gamma-aminobutyric acid (GABA) B receptor, 1, GABAB Receptor (phospho S923), GABAB Receptor (phospho Ser923), GABAB Receptor (pS923), GABAB Receptor (pSer923), GABAB Receptor phospho S923, GABAB Receptor phospho Ser923, Phospho GABAB Receptor (S923), Phospho GABAB Receptor (Ser923), Phospho GABAB Receptor (pS923), Phospho GABAB Receptor (pSer923)
Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes.
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.