GeneTex
United States (US)

GABA B Receptor 2 (phospho Ser783) antibody

GABAB-Receptor-phospho-Ser783-antibody-R2-Subunit__GTX31019-1_18121410_870.jpg

Cat No. GTX31019

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC
Reactivity Rat
APPLICATION

Application Note

Optimal working dilutions should be determined experimentally by the end user.

Calculated MW

102 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

100 μl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 conjugated to KLH

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Gamma-Aminobutyric Acid Type B Receptor Subunit 2,Gpr51,Gabbr2

Cellular Localization

Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.

Background

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Database

Research Area

DATA IMAGES
GABAB-Receptor-phospho-Ser783-antibody-R2-Subunit__GTX31019-1_18121410_870.jpg

GTX31019 WB Image

Western blot of rat synaptic membrane showing specific immunolabeling of the ~102 k GABAB R2 protein phosphorylated at Ser783 (control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase).

Package List Price ($)
$ 329