APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 40 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Mouse, Rat, Bovine, Dog, Hamster, Monkey, Bat, Gibbon, Gorilla, Horse, Marmoset, Panda, Platypus(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 18 amino acid peptide from 7th transmembrane domain of human GALR2.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375238
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
galanin receptor 2 , GAL2R , GALNR2 , GALR2 , Galanin Receptor 2
Cellular Localization
Cell membrane
Background
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX70681 IHC-P Image
IHC-P analysis of human brain, glioblastoma tissue using GTX70681 GALR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70681 IHC-P Image
IHC-P analysis of human ovary, carcinoma tissue using GTX70681 GALR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70681 IHC-P Image
IHC-P analysis of human skin, melanoma tissue using GTX70681 GALR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70681 IHC-P Image
IHC-P analysis of ovary, carcinoma tissue using GTX70681 GALR2 antibody.
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GTX70681 IHC-P Image
IHC-P analysis of brain, medulla tissue using GTX70681 GALR2 antibody.
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GTX70681 IHC-P Image
IHC-P analysis of human brain, neurons and glia tissue using GTX70681 GALR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70681 IHC-P Image
IHC-P analysis of human pancreas, carcinoma tissue using GTX70681 GALR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX70681 IHC-P Image
IHC-P analysis of human skin hair follicle tissue using GTX70681 GALR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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REFERENCE
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REVIEW
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