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GAPDH antibody [GT239] (HRP)

Anti-GAPDH antibody [GT239] (HRP) used in Western Blot (WB). GTX627408-01
Anti-GAPDH antibody [GT239] (HRP) used in IHC (Paraffin sections) (IHC-P). GTX627408-01

Cat. No. GTX627408-01

Reference 409

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 GT239

Isotype

 IgG2b

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat, Hamster
Package
100 μl ($399),
25 μl ($169)
See all GAPDH products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:5000-1:20000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

36 kDa. ( Note )

Predict Reactivity

Zebrafish, Rabbit, Sheep, Bovine, Cat, Dog, Chicken, Guinea pig, Pig, Xenopus tropicalis, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.05M Tris (pH7.4), 0.15M NaCl, 1%BSA

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.62 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human GAPDH. The exact sequence is proprietary.

Purification

Affinity purified by Protein G.

Conjugation

Horseradish peroxidase(HRP)

RRID

AB_2888014

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

glyceraldehyde-3-phosphate dehydrogenase , G3PD , GAPD , HEL-S-162eP

Cellular Localization

Cytoplasm , perinuclear region , Membrane

Background

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-GAPDH antibody [GT239] (HRP) used in Western Blot (WB). GTX627408-01

GTX627408-01 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with GAPDH antibody [GT239] (HRP) (GTX627408-01) diluted at 1:10000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] (HRP) used in IHC (Paraffin sections) (IHC-P). GTX627408-01

GTX627408-01 IHC-P Image

GAPDH antibody [GT239] (HRP) detects GAPDH antibody protein at cytoplasm in rat testis by immunohistochemical analysis.
Sample: Paraffin-embedded rat testis.
GAPDH antibody [GT239] (HRP) (GTX627408-01) diluted at 1:200.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

Application Reference

Zengel J et al. Nat Methods 2023; 20 (7) : 1070-1081 Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.

Clone Reference

Escalante-Covarrubias Q et al. Nat Commun 2023; 14 (1):1685 Time-of-day defines NAD(+) efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice.
Application : WB
Reactivity : Mouse
Shilts J et al. PLoS Biol 2023; 21 (2):e3001959 LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
Despic V et al. Nature 2023; 614 (7947):358-366 mRNA ageing shapes the Cap2 methylome in mammalian mRNA.
Quiles JM et al. Sci Signal 2023; 16 (770):eabo4457 Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.
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REVIEW

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Application Reference
Zengel J et al. Nat Methods 2023; 20 (7):1070-1081 Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.
S?nchez-Ram?rez E et al. J Cell Biol 2022; 221 (12) Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis.
Application : WB
Reactivity : Human
Ma S et al. PLoS One 2022; 17 (9):e0274618 Knockout of Trpa1 accelerates age-related cardiac fibrosis and dysfunction.
Taura M et al. Proc Natl Acad Sci U S A 2022; 119 (20):e2011665119 APOBEC3A regulates transcription from interferon-stimulated response elements.
Revollo L et al. Blood 2022; 139 (1):104-117 The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.
Willis A et al. Mol Neurobiol 2022; Enzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation.
Application : WB
Reactivity : Mouse
Antonino Asaro et al. J Cell Sci 2021; 134 (20) ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling.
Application : WB
Reactivity : Mouse, Hamster
Revollo L. et al. bioRxiv 2021; (Epub) The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.
Application : WB
Reactivity : Human
Klatt D et al. Cells 2020; 9 (10) Competitive sgRNA Screen Identifies p38 MAPK as a Druggable Target to Improve HSPC Engraftment.
Application : WB
Reactivity : Human
Wang L et al. Proc Natl Acad Sci U S A 2020; 117 (1):563-572 A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
Kim DJ et al. J Virol 2020; 94 (22) RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression.
Application : WB
Reactivity : Mouse
Phatarpekar PV et al. J Cell Biol 2020; 219 (11) The septin cytoskeleton regulates natural killer cell lytic granule release.
Application : WB
Reactivity : Human
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Application : WB
Reactivity : Human
Lu RA et al. Front Pharmacol 2020; 11:469 Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.
Application : WB
Reactivity : Human
Alex G. Johnson et al. bioRxiv 2019; (Epub) A memory of RPS25 loss drives resistance phenotypes.
Application : WB
Reactivity : Human
Ma S et al. Am J Physiol Renal Physiol 2019; 317 (3):F623-F631 Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury.
Application : WB
Reactivity : Mouse
Taura M et al. Proc Natl Acad Sci U S A 2019; 116 (6):2282-2289 Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.
Application : WB
Reactivity : Human
Jessen TN et al. Exp Cell Res 2019; 374 (1):128-139 VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.
Application : WB
Reactivity : Human
Jessen TN et al. Exp Cell Res 2017; 361 (2):265-276 VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Olabisi OA et al. Proc Natl Acad Sci U S A 2016; 113 (4):830-7 APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
Application : WB
Reactivity : Human
Schrecengost RS et al. Mol Cancer Res 2015; 13 (12):1591-601 Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
Application : WB
Reactivity : Human
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Application : WB
Reactivity : Human
Clone Reference
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Escalante-Covarrubias Q et al. Nat Commun 2023; 14 (1):1685 Time-of-day defines NAD(+) efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice.
Application : WB
Reactivity : Mouse
Shilts J et al. PLoS Biol 2023; 21 (2):e3001959 LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
Despic V et al. Nature 2023; 614 (7947):358-366 mRNA ageing shapes the Cap2 methylome in mammalian mRNA.
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