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GAPDH antibody [GT239]

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in IHC (Paraffin sections) (IHC-P). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

Cat No. GTX627408

Reference 222
6

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 GT239

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-P, EMSA

Reactivity

 Human, Mouse, Rat, Zebrafish, Yeast, Drosophila, Pig, Monkey, E. coli
Package
100 μl ($329),
25 μl ($169)
See all GAPDH products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:20000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
EMSA Assay dependent
Not tested in other applications.

Calculated MW

36 kDa. ( Note )

Positive Control

293T , NIH-3T3 , mouse brain , PC-12 , rat brain , E. coli M15 , Drosophila , yeast , zebrafish

Predict Reactivity

Rabbit, Sheep, Bovine, Cat, Dog, Chicken, Guinea pig, Xenopus laevis, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human GAPDH. The exact sequence is proprietary.

Purification

Affinity purified by Protein G.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

glyceraldehyde-3-phosphate dehydrogenase , G3PD , GAPD , HEL-S-162eP

Cellular Localization

Cytoplasm , perinuclear region , Membrane

Background

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

Sample (30 μg of whole cell lysate)
A: Drosophila
10% SDS PAGE
GTX627408 diluted at 1:5000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.
A. 30 μg yeast whole cell lysate/extract
10% SDS-PAGE
GAPDH antibody [GT239] (GTX627408) dilution: 1:10000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.
A. 30 μg 293T whole cell lysate/extract
B. 30 μg NIH-3T3 whole cell lysate/extract
C. 30 μg mouse brain lysate/extract
D. 30 μg PC-12 whole cell lysate/extract
E. 30 μg rat brain lysate/extract
10% SDS-PAGE
GAPDH antibody [GT239] (GTX627408) dilution: 1:10000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX627408

GTX627408 ICC/IF Image

GAPDH antibody [GT239] detects GAPDH protein at cytoplasm by immunofluorescent analysis.
Sample: HeLa cells were fixed in ice-cold MeOH for 5 min.
Green: GAPDH stained by GAPDH antibody [GT239] (GTX627408) diluted at 1:500.
Blue: Hoechst 33342 staining.

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.
A. 20 μg 293T whole cell lysate/extract
B. 10 μg 293T whole cell lysate/extract
C. 5 μg 293T whole cell lysate/extract
D. 1 μg 293T whole cell lysate/extract
10% SDS-PAGE
GAPDH antibody [GT239] (GTX627408) dilution: 1:10000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] used in IHC (Paraffin sections) (IHC-P). GTX627408

GTX627408 IHC-P Image

GAPDH antibody [GT239] detects GAPDH protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse kidney.
GAPDH stained by GAPDH antibody [GT239] (GTX627408) diluted at 1:200.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with (GTX627408) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

Whole cell extract (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with GAPDH antibody [GT239] (GTX627408) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

The WB analysis of GAPDH antibody [GT239] was published by Le CT and colleagues in the journal PLoS One in 2018 (PMID: 29444136)

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

The WB analysis of GAPDH antibody [GT239] was published by Al-Sawaf O and colleagues in the journal Sci Rep in 2014 (PMID: 24406502)

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

The WB analysis of GAPDH antibody [GT239] was published by Chou CK and colleagues in the journal Int J Mol Sci in 2015 (PMID: 26151845)

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

The WB analysis of GAPDH antibody [GT239] was published by Chou CK and colleagues in the journal Int J Mol Sci in 2015 (PMID: 26151845)

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

The WB analysis of GAPDH antibody [GT239] was published by Le CT and colleagues in the journal PLoS One in 2018 (PMID: 29444136)

Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408

GTX627408 WB Image

Various tissue extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with GAPDH antibody [GT239] (GTX627408) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Wantoch von Rekowski K et al. Biomolecules 2019; 9 (12) The Impact of Integrin-Mediated Matrix Adhesion on Cisplatin Resistance of W1 Ovarian Cancer Cells.
Application : WB
Reactivity : Human
Galmozzi A et al. Nature 2019; 576 (7785) : 138-142 PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
Application : WB
Botrugno OA et al. Haematologica 2019; (Epub) ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies.
Application : WB
Reactivity : Human
Majer O et al. Nature 2019; 575 (7782) : 371-374 Release from UNC93B1 reinforces the compartmentalized activation of select TLRs.
Application : WB
Reactivity : Human
Choquet K et al. J Biol Chem 2019; 294 (18) : 7445-7459 Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA BC200.
Show More +
Submit a Reference

REVIEW

GAPDH antibody [GT239] Cat No. GTX627408

Rating
( Average 4.5 based on 6 users reviews)
Application
Western Blot(WB)
( Average 4.5 based on 6 users reviews)
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Date : Anonymous submitted on 24-Apr-2017
Score :
Application Tested : WB
Sample Species : Rat
Sample : Brain tissue
Amount used : 50 μg
Blocking : 3% BSA in TBST, 23°C, 1Hr
Primary Antibody : 1:10000, 4°C, 16Hr
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Date : Anonymous submitted on 30-Jun-2014
Score :
Application Tested : WB
Sample Species : Hu
Sample : KATOIII cells, MKN45 cells
Amount used : 100μg
Blocking : skim milk, 25°C, 1Hr
Primary Antibody : 1:5000, 4°C, 16Hr
Lane Description : Lane1:KATOIII cells, Lane2:MKN45 cells
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Date : Anonymous submitted on 18-Apr-2014
Score :
Application Tested : WB
Sample Species : Hu
Sample : SHSY-5Y cells
Amount used : 30μg
Blocking : 5% Skim milk in TBST, 25°C, 2Hr
Primary Antibody : 1:5000, 4°C, 16Hr
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Date : Anonymous submitted on 06-Mar-2014
Score :
Application Tested : WB
Sample Species : Rat
Sample : PC12 cells
Amount used : 20μg
Blocking : 5% nonfat milk, 22°C, 0.5Hr
Primary Antibody : 1:1000, 22°C, 2Hr
Figure Note : starreivew courtesy of Xiaobei(Laboratory of UCSD)
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Date : Anonymous submitted on 06-Feb-2012
Score :
Application Tested : WB
Sample Species : Hu
Sample : 293T cells
Amount used : 30μg
Blocking : TBST with 5% milk, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Anti-GAPDH antibody [GT239] used in Western Blot (WB). GTX627408
Date : Anonymous submitted on 06-Feb-2012
Score :
Application Tested : WB
Sample Species : Hu
Sample : M10 cells
Amount used : 40μg
Blocking : TBST with 5% milk, 25°C, 1Hr
Primary Antibody : 1:5000, 25°C, 1Hr
Show More +
Submit a Review
Application Reference
Nagano M et al. Commun Biol 2019; 2 (1):419 Rab5-mediated endosome formation is regulated at the trans-Golgi network.
Application : WB
Wantoch von Rekowski K et al. Biomolecules 2019; 9 (12) The Impact of Integrin-Mediated Matrix Adhesion on Cisplatin Resistance of W1 Ovarian Cancer Cells.
Application : WB
Reactivity : Human
Galmozzi A et al. Nature 2019; 576 (7785):138-142 PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
Application : WB
Botrugno OA et al. Haematologica 2019; (Epub) ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies.
Application : WB
Reactivity : Human
Majer O et al. Nature 2019; 575 (7782):371-374 Release from UNC93B1 reinforces the compartmentalized activation of select TLRs.
Application : WB
Reactivity : Human
Choquet K et al. J Biol Chem 2019; 294 (18):7445-7459 Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA BC200.
Nagano M et al. Commun Biol 2019; 2:419 Rab5-mediated endosome formation is regulated at the trans-Golgi network.
Application : WB
Lin ST et al. Front Physiol 2019; 10:1308 Transcription Factor Elf3 Modulates Vasopressin-Induced Aquaporin-2 Gene Expression in Kidney Collecting Duct Cells.
Application : WB
Reactivity : Mouse
Ritter A et al. Cells 2019; 8 (10) Subcutaneous and Visceral Adipose-Derived Mesenchymal Stem Cells: Commonality and Diversity.
Application : WB
Reactivity : Human
Schmidlin T et al. Cell Syst 2019; 9 (4):366-374.e5 High-Throughput Assessment of Kinome-wide Activation States.
Application : WB
Reactivity : Human
Ogola BO et al. Front Endocrinol (Lausanne) 2019; 10:586 G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress.
Application : WB
Reactivity : Rat
Gatz C et al. Front Neurol 2019; 10:562 Identification of Cellular Pathogenicity Markers for SIL1 Mutations Linked to Marinesco-Sj?gren Syndrome.
Application : WB
Reactivity : Human
Vibhuti Vyas et al. FASEB 2019; (Epub) Adiponectin links maternal metabolism to uterine contractility.
Application : WB
Arantxa Agote-Ar?n et al. bioRxiv 2019; (Epub) Spatial control of nucleoporin assembly by Fragile X-related proteins.
Application : WB
Reactivity : Human
Hu Y et al. Mol Reprod Dev 2019; MiR-8-3p regulates hyperthermia-induced lactate secretion by targeting PPP2R5B in boar Sertoli cells.
Application : WB
Reactivity : Human
Majer O et al. Nature 2019; UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.
Application : WB
Akimoto Y et al. Am J Physiol Renal Physiol 2019; O-GlcNAcylation and Phosphorylation of β-Actin Serine199 in Diabetic Nephropathy.
Bolea I et al. Elife 2019; 8 Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome.
Application : WB
Reactivity : Mouse
Peiris MN et al. Haematologica 2019; (Epub) Oncogenic fusion protein BCR-FGFR1 requires BCR-mediated oligomerization and chaperonin Hsp90 for activation.
Application : WB
Reactivity : Human
YingGuo et al. CJD 2019; (Epub) MicroRNA-15a inhibits GLUT4 translocation and impairs glucose metabolism in L6 skeletal muscle via targeting of VAP-A.
Application : WB
Kreis NN et al. Cancers (Basel) 2019; 11 (7) Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic Cells.
Application : WB
Reactivity : Human
Andreazza S et al. Nat Commun 2019; 10 (1):3280 Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila.
Application : WB
Reactivity : Drosophila
Fantini V et al. Cells 2019; 8 (8) Bioink Composition and Printing Parameters for 3D Modeling Neural Tissue.
Inserte J et al. J Mol Cell Cardiol 2019; 133:164-173 High-fat diet improves tolerance to myocardial ischemia by delaying normalization of intracellular PH at reperfusion.
Application : WB
Ham S et al. Mol Cells 2019; 42 (6):480-494 Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates.
Application : WB
Reactivity : Human
Cheng YP et al. Int J Mol Sci 2019; 20 (13) Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells.
Application : WB
Reactivity : Human
Woodall BP et al. JCI Insight 2019; 5 Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
Application : WB
Berenice M?rquez-Valadez et al. Front. Neurosci. 2019; (Epub) The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist.
Application : WB
Reactivity : Rat
Lampert MA et al. Autophagy 2019; 15 (7):1182-1198 BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.
Application : WB
Reactivity : Mouse
Goren I et al. Nitric Oxide 2019; 87:31-42 Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.
Application : WB
Reactivity : Mouse
Chou CK et al. Environ Toxicol 2019; 34 (4):401-414 Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes.
Application : WB
Reactivity : Human
Bang BR et al. J Virol 2019; (Epub) Regulation of HCV infection by Cellular Retinoic Acid Binding Proteins through the modulation of lipid droplet abundance.
Application : WB
Reactivity : Human
Brifault C et al. Glia 2019; (Epub) LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.
Application : WB
Reactivity : Mouse
Tseng HW et al. Cancers (Basel) 2019; 11 (2) * treatment suppresses melanoma cell growth and motility through modulation of microrna expression.
Application : WB
Reactivity : Human
Garcia-Bermudez J et al. Nature 2019; 567 (7746):118-122 Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Application : WB
Reactivity : Human
Hu CM et al. Cell Metab 2019; (Epub) High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.
Application : WB
Reactivity : Human
Takeuchi S et al. Am J Pathol 2019; 189 (2):391-404 Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus.
Application : WB
Reactivity : Monkey
Jakubzig B et al. Cancers (Basel) 2018; 10 (12) Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells-Deciphering Novel Potential Targets for a Cell Sensitization.
Application : WB
Ponert JM et al. Molecules 2018; 23 (10) Unfractionated and Low Molecular Weight * Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.
Application : WB
Reactivity : Human
Chakraborty P et al. Nat Commun 2018; 9 (1):4346 DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
Application : WB
Reactivity : Human
Erol C. Bayraktar et al. bioRxiv 2018; (Epub) MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.
Application : WB
Reactivity : Mouse
Tiwari PM et al. Nat Commun 2018; 9 (1):3999 Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.
Application : WB
Reactivity : Mouse
Rodrigues ACZ et al. Acta Physiol (Oxf) 2018;:e13195 The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.
Application : WB
Reactivity : Mouse
Snyder B et al. Horm Behav 2018; 106:62-73 Androgens modulate chronic intermittent hypoxia effects on brain and behavior.
Application : WB
Reactivity : Rat
Baek JH et al. Am J Pathol 2018; (Epub) deletion of the mitochondrial complex-iv cofactor heme a/farnesyltransferase causes focal segmental glomerulosclerosis and * response.
Application : WB
Reactivity : Mouse
Ohta S et al. Mol Cell Proteomics 2018; (Epub) Quantitative proteomics of the mitotic chromosome scaffold reveals the association of BAZ1B with chromosomal axes.
Application : WB
Reactivity : Human
Olivia Majer et al. bioRxiv 2018; (Epub) Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity.
Application : WB
Olivia Majer et al. bioRxiv 2018; (Epub) An essential checkpoint for TLR9 signaling is release from 1 Unc93b1 in endosomes.
Application : WB
Grimsey NJ et al. Cell Rep 2018; 24 (12):3312-3323.e5 A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.
Application : WB
Reactivity : Human
Lai CY et al. J Neurosci 2018; 38 (43):9160-9174 Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates mGluR5 Transcription for Neuropathic Allodynia.
Application : WB
Reactivity : Rat
Zhang Q et al. Oncol Rep 2018; (Epub) * improves adoptive carbonic anhydrase-ix-specific chimeric antigen receptor-modified nk92 cell therapy in mouse models of human renal cell carcinoma.
Takaichi Y et al. J Neuropathol Exp Neurol 2018; (Epub) Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy.
Application : WB
Reactivity : Mouse
SHIJIE HE et al. bioRxiv 2018; (Epub) The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration.
Application : WB
Reactivity : Human
Snuderl M et al. Nat Commun 2018; 9 (1):2868 Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.
Application : WB
Reactivity : Human
Ou Y et al. Int J Clin Exp Pathol 2018; 11 (6):3052-3060 Silencing profilin-1 confers protection from oxLDL injury in human vascular endothelial cells.
Application : WB
Reactivity : Human
Lu Y et al. Neural Regeneration Research 2018; 13 (7):1195-1203 Houshiheisan and its components promote axon regeneration after ischemic brain injury.
Application : WB
Reactivity : Rat
AshleighWillis et al. Journal of Neuroscience Methods 2018; (Epub) Distortion of protein analysis in primary neuronal cultures by serum albumin from culture medium: a methodological approach to improve target protein quantification.
Application : WB
Reactivity : Mouse
Kretschmer J et al. RNA 2018; (Epub) The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.
Application : WB
Reactivity : Human
Daniels LJ et al. Cardiovasc Diabetol 2018; 17 (1):89 Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Application : WB
Reactivity : Rat
Chung YH et al. Lab Invest 2018; (Epub) BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling.
Application : WB
Reactivity : Mouse
Zhang N et al. J Cancer Sci Ther 2018; 10 (3) Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Application : WB
Reactivity : Human
Hayashi K et al. Sci Signal 2018; 11 (528) the interaction between ikkα and lc3 promotes type i * production through the tlr9-containing laposome.
Application : WB
Reactivity : Mouse
Miscianinov V. et al. Molecular Therapy 2018; (Epub) MicroRNA-148b targets the TGF-β pathway to regulate angiogenesis and endothelialto-mesenchymal transition during skin wound healing.
Application : WB
Reactivity : Human
Lee CH et al. Mol Cell 2018; 70 (3):435-448.e5 Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.
Application : WB
Reactivity : Mouse
Mrazkova B et al. Aging (Albany NY) 2018; 10 (3):434-462 Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence.
Application : WB
Reactivity : Human
Tanabe Y et al. Oncotarget 2018; 9 (18):14428-14443 IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.
Application : WB
Reactivity : Human
Tian L et al. Hindawi 2018; (Epub) Electroacupuncture at ST-36 protects interstitial cells of Cajal via sustaining heme oxygenase-1 positive M2 macrophages in the stomach of diabetic mice.
Application : WB
Reactivity : Mouse
Stefanovic-Barrett S et al. EMBO Rep 2018; (Epub) MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Application : WB
Reactivity : Human
Macdougall CE et al. Cell Metab 2018; 27 (3):588-601.e4 Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.
Application : WB
Reactivity : Mouse
Gomez-Virgilio L et al. Mol Neurobiol 2018; (Epub) Soluble Factors from Human Olfactory Neural Stem/Progenitor Cells Influence the Fate Decisions of Hippocampal Neural Precursor Cells.
Application : WB
Reactivity : Human
Juneja M et al. J Neurol Neurosurg Psychiatry 2018; (Epub) PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease.
Application : WB
Reactivity : Mouse
Lan B et al. Am J Physiol Lung Cell Mol Physiol 2018; (Epub) Transient stretch induces cytoskeletal fluidization through the severing action of cofilin.
Application : WB
Reactivity : Human
Coppe A et al. Hum Mutat 2018; (Epub) Somatic mutations activating Wiskott-Aldrich syndrome protein concomitant with RAS pathway mutations in Juvenile myelomonocytic leukemia patients.
Application : WB
Schultz CR et al. Biochem J 2018; (Epub) Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
Application : WB
Reactivity : Human
Nguyen G et al. Biochem Biophys Res Commun 2018; 495 (4):2649-2656 * ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and gpr91 inhibition.
Application : WB
Reactivity : Human, Mouse
Thompson EL et al. Nucleic Acids Res 2017; 45 (20):11837-11857 FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.
Gimpel P et al. Curr Biol 2017; 27 (19):2999-3009.e9 Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Lee YH et al. Oncol Lett 2017; 14 (1):171-179 DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells.
Application : WB
Reactivity : Human
Damiani E et al. Sci Rep 2017; 7:41959 Platelet activating factor-induced expression of p21 is correlated with histone acetylation.
Hammerling BC et al. Nat Commun 2017; 8:14050 A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Zhang C et al. Mol Oncol 2017; 11 (3):280-294 TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
Bressan RB et al. Development 2017; 144 (4):635-648 Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells.
Lin YY et al. Mar Drugs 2017; 15 (1) Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis.
Yang PY et al. Oncotarget 2017; 8 (3):4196-4207 Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation.
Shentu TP et al. Sci Rep 2017; 7 (1):18052 Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation.
Application : WB
Reactivity : Human
Yamamoto W et al. J Cell Sci 2017; (Epub) Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during yeast receptor-mediated endocytosis.
Application : WB
Reactivity : Yeast
Kaehler M et al. Oncotarget 2017; 8 (54):92018-92031 MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells.
Application : WB
Reactivity : Human
Newman EA et al. Cell Death Dis 2017; 8 (12):3208 Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation.
Application : WB
Reactivity : Human
Su WC et al. J Virol 2017; (Epub) Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles.
Jessen TN et al. Exp Cell Res 2017; (Epub) VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Application : WB
Reactivity : Human
Li F et al. Diabetologia 2017; (Epub) loss of renal snx5 results in impaired ide activity and * resistance in mice.
Application : WB
Reactivity : Human
Lee CH et al. bioRxiv 2017; (Epub) Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin.
Application : WB
Reactivity : Mouse
Lee CH et al. bioRxiv 2017; (Epub) Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2).
Application : WB
Reactivity : Mouse
Larhammar M et al. J Neurosci 2017; (Epub) The Ste20 family kinases MAP4K4, MINK1 and TNIK, converge to regulate stress induced JNK signaling in neurons.
Application : WB
Reactivity : Mouse
Brifault C et al. J Biol Chem 2017; (Epub) Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuro-inflammation.
Application : WB
Reactivity : Mouse
De Gasperi R et al. Sci Rep 2017; 7 (1):12888 Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers.
Application : WB
Reactivity : Mouse
Garza-Contreras J et al. eNeuro 2017; 4 (4) Presence of Androgen Receptor Variant in Neuronal Lipid Rafts.
Application : WB
Reactivity : Rat
Rong X et al. J Clin Invest 2017; (Epub) ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Application : WB
Reactivity : Mouse
Tang B et al. Int J Cancer 2017; (Epub) microrna-324-5p regulates stemness, pathogenesis and sensitivity to * in multiple myeloma cells by targeting hedgehog signaling.
Application : WB
Reactivity : Human
Chung YH et al. Int J Mol Sci 2017; 18 (8) MiR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition and Upregulates Expression of Tight Junction Protein Claudin-5 in Human Upper Tract Urothelial Carcinoma Cells.
Application : WB
Reactivity : Human
King HA et al. Sci Rep 2017; 7 (1):6542 Generation of ribosome imprinted polymers for sensitive detection of translational responses.
Application : WB
Reactivity : Human
Bouhy D et al. Acta Neuropathol 2017; (Epub) A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.
Application : WB
Reactivity : Mouse
Bartova M et al. Clin Exp Metastasis 2017; Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.
Application : WB
Reactivity : Human
Joly P et al. PLoS One 2017; 12 (6):e0179369 ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency.
Application : WB
Reactivity : Human
Hammerling BC et al. Small GTPases 2017;:0 Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Application : WB
Reactivity : Mouse
Wang VY et al. Mol Cell 2017; Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
Application : WB
Reactivity : Mouse
Preusner M et al. Mol Cell 2017; Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.
Application : WB
Reactivity : Mouse
Lee KH et al. Sci Rep 2017; 7 (1):4787 Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway.
Application : WB
Reactivity : Mouse
Pillay S et al. J Virol 2017; AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR.
Application : WB
Reactivity : Human
Fang F et al. Sci Rep 2017; 7 (1):3868 Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.
Application : WB
Reactivity : Mouse
Park JW et al. Mod Pathol 2017; (Epub) FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Application : WB
Reactivity : Human
Zeng L et al. Biochem Pharmacol 2017; (Epub) MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation.
Application : WB
Reactivity : Human
Xiao X et al. Nucleic Acids Res 2017; (Epub) Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Application : WB
Reactivity : Human
Wu JH et al. J Eur Acad Dermatol Venereol 2017; (Epub) Dysregulation of the MEK/ERK/MNK1 signaling cascade by middle T antigen of the trichoydsplasia spinulosa polyomavirus.
Application : WB
Reactivity : Human
Scherer SL et al. J Biol Chem 2017; (Epub) Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.
Application : WB
Reactivity : Mouse
Zhang J et al. J Biol Chem 2017; (Epub) Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Application : ICC/IF
Reactivity : Mouse
Guichard J et al. Am J Physiol Heart Circ Physiol 2017;:ajpheart.00027.2017 Desmin Loss and Mitochondrial Damage Precede Left Ventricular Systolic Failure in Volume Overload Heart Failure.
Application : WB
Reactivity : Rat
Dart AE et al. Oncogene 2017; (Epub) The drebrin/EB3 pathway drives invasive activity in prostate cancer.
Application : WB
Reactivity : Human
Fujiki K et al. J Biol Chem 2017; (Epub) Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure.
Application : WB
Reactivity : Human
Respondek D et al. PLoS One 2017; 12 (3):e0173259 PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
Application : WB
Chen Y et al. Cell Signal 2017; 33:107-121 Casein Kinase 2 Interacting Protein-1 regulates * and M2 inflammatory macrophage polarization.
Delaney JR et al. Nat Commun 2017; 8:14423 Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.
Wang T et al. Cell 2017; (Epub) Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
Application : WB
Reactivity : Human
Baba Y et al. Int J Mol Sci 2017; 18 (2) Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.
Application : WB
Reactivity : Human
Frasca D et al. Mech Ageing Dev 2017; (Epub) Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.
Application : WB
Reactivity : Mouse
Huang WY et al. J Dermatol Sci 2017; (Epub) Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction.
Application : WB
Reactivity : Rat
Hutt DM et al. Methods Mol Biol 2017; 1510:77-91 Using Histone Deacetylase Inhibitors to Analyze the Relevance of HDACs for Translation.
Application : WB
Reactivity : Human
Zhou W et al. Int J Mol Med 2016; 38 (5):1481-1489 Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
Gan Z et al. Cell Syst 2016; 3 (3):252-263.e8 Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration.
Application : WB
Reactivity : Human
Zhang D et al. Oncotarget 2016; 7 (43):69149-69158 Targeting the ERK pathway for the treatment of Cushing's disease.
Application : WB
Reactivity : Mouse
Ahmad F et al. Sci Rep 2016; 6:28056 Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
Application : WB
Reactivity : Mouse
Xiao X et al. Nat Commun 2016; 7:12193 Crystal structures of APOBEC3G N-domain alone and its complex with DNA.
Application : WB
Reactivity : Human
Jiang P et al. Oncotarget 2016; 7 (36):57932-57942 Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.
Application : WB
Reactivity : Human
Starokadomskyy P et al. Nat Immunol 2016; 17 (5):495-504 dna polymerase-α regulates the activation of type i *s through cytosolic rna:dna synthesis.
Application : WB
Reactivity : Human
Paudyal A et al. J Physiol 2016; 594 (12):3287-305 Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure.
Application : WB
Reactivity : Pig
Chang WT et al. Anticancer Agents Med Chem 2016; (Epub) 9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis.
Application : WB
Reactivity : Human
Schultz AS et al. Mol Cell Biol 2016; (Epub) Activation-dependent TRAF3 exon 8 alternative splicing is controlled by CELF2 and hnRNP C binding to an upstream intronic element.
Application : WB
Reactivity : Human
Yang HH et al. Proteomics Clin Appl 2016; (Epub) the putative involvement of actin binding proteins and cytoskeleton proteins in pathological mechanisms of * cystitis - revealed by a prospective pilot study using proteomic approaches.
Application : WB
Reactivity : Human
Chroma K et al. Oncogene 2016; (Epub) Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.
Application : WB
Reactivity : Human
Martinez-Castillo M et al. PLoS One 2016; 11 (11):e0165971 A Subpopulation of the K562 Cells Are Killed by Curcumin Treatment after G2/M Arrest and Mitotic Catastrophe.
Application : WB
Reactivity : Human
Korinek M et al. Phytomedicine 2016; 23 (14):1706-1715 Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx.
Edmonds S et al. ACS Nano 2016; (Epub) Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines.
Application : WB
Reactivity : Mouse
Sheets JN et al. Oncogenesis 2016; 5 (10):e264 SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance.
Application : WB
Reactivity : Human
Zhou W et al. Int J Mol Med 2016; 38:1481-1489 Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
Application : WB
Reactivity : Rat
Kuga T et al. Sci Rep 2016; 6:34472 Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON.
Wu JH et al. J Med Virol 2016; Molecular mechanisms supporting a pathogenic role for human polyomavirus 6 small T antigen: Protein phosphatase 2A targeting and MAPK cascade activation.
Application : WB
Reactivity : Human
Aryal B et al. Nat Commun 2016; 7:12313 ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Application : WB
Reactivity : Mouse
Tsai WT et al. J Biol Chem 2016; 291 (37):19299-311 Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy.
Application : WB
Reactivity : Mouse
Steven S et al. Br J Pharmacol 2016; Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.
Application : WB
Reactivity : Human
Wilhelmi I et al. Nat Commun 2016; 7:12347 Sec16 alternative splicing dynamically controls COPII transport efficiency.
Application : WB
Reactivity : Human
Smith TH et al. J Biol Chem 2016; (Epub) Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-arrestins.
Application : WB
Reactivity : Human
Hahm ER et al. Cell Cycle 2016;:43112 c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells.
Application : WB
Reactivity : Human
Tsai KW et al. Sci Rep 2016; 6:28176 Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer.
Application : WB
Reactivity : Human
Yu T et al. Cell Death Dis 2016; 7 (6):e2255 KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Application : WB
Reactivity : Human
Mankouri J et al. J Virol 2016; (Epub) Release of infectious hepatitis C virus from Huh7 cells occurs via a trans-Golgi network to endosome pathway independent of VLDL.
Application : WB
Reactivity : Human
Kuga T et al. Sci Rep 2016; 6:26557 FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.
Application : WB
Reactivity : Human
Toste PA et al. Mol Cancer Res 2016; 14 (5):437-47 Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK.
Application : WB
Reactivity : Human
Delphine B. et al. JND 2016; Preprint:43118 Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus.
Pacold ME et al. Nat Chem Biol 2016; 12 (6):452-8 A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Li YH et al. J Biol Chem 2016; 291 (19):10277-92 Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
Application : WB
Reactivity : Human
Lisa J. Bain et al. Toxicol Rep 2016; 3:405-413 Arsenic inhibits stem cell differentiation by altering the interplay between the Wnt3a and Notch signaling pathways.
Application : WB
Reactivity : Mouse
Moreno-Lorenzana D et al. Cell Cycle 2016; (Epub):0 CDKIs p18INK4c and p57Kip2 are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Application : WB
Reactivity : Human
Rowe ER et al. J Biol Chem 2016; 291 (13):6664-78 Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.
Application : WB
Reactivity : Yeast, Monkey
Pillay S et al. Nature 2016; ([Epub ahead of print]) An essential receptor for adeno-associated virus infection.
Application : WB
Reactivity : Human
Egerman MA et al. Cell Metab 2015; 22 (1):164-74 GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
Application : WB
Reactivity : Mouse
Ma F et al. J Immunol 2015; 194 (4):1545-54 Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.
Application : WB
Reactivity : Mouse
Tian H et al. Mol Cancer Res 2015; 13 (4):784-94 Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.
Application : WB
Reactivity : Human
Kelley RA et al. J Biol Chem 2015; 290 (8):5041-52 Retbindin is an extracellular riboflavin-binding protein found at the photoreceptor/retinal pigment epithelium interface.
Application : WB
Reactivity : Mouse
Zhang X et al. Clin Cancer Res 2015; 21 (20):4698-708 SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.
Application : WB
Reactivity : Human
Huang TT et al. Oncotarget 2015; 6 (20):18012-26 The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis.
Application : WB
Reactivity : Human
Zengel J et al. J Virol 2015; 89 (14):7338-47 Roles of Phosphorylation of the Nucleocapsid Protein of Mumps Virus in Regulating Viral RNA Transcription and Replication.
Application : WB
Reactivity : Monkey
Jo A et al. Biomed Res Int 2015; 2015:305716 Efficient Mitochondrial Genome Editing by CRISPR/Cas9.
Application : WB
Reactivity : Human
Grimsey NJ et al. J Cell Biol 2015; 210 (7):1117-31 Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.
Application : WB
Reactivity : Human
Lin TB et al. J Neurosci 2015; 35 (50):16545-60 Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
Application : WB
Reactivity : Rat
Wu JC et al. Sci Rep 2015; 5:18476 Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.
Application : WB
Reactivity : Human
Shi J et al. Mol Cell Biol 2015; 35 (19):512011 Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.
Kohl S et al. Nat Genet 2015; 47 (7):757-65 Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.
Paret C et al. Oncotarget 2015; 6 (28):25356-67 CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer.
Jacinto FV et al. Genes Dev 2015; 29 (12):1224-38 The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.
Huber RM et al. Oncotarget 2015; 6 (4):2134-47 DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance.
Wei-Chou Lin et al. Am J Cancer Res 2015; 5 (11):3350-3362 mln4924, a novel nedd8-activating enzyme inhibitor, exhibits antitumor activity and enhances *-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study.
Application : WB
Reactivity : Human
Chou CK et al. Int J Mol Sci 2015; 16 (7):15104-17 BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9.
Application : WB
Reactivity : Human
Kubli DA et al. PLoS One 2015; 10 (6):e0130707 PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.
Application : WB
Reactivity : Mouse
Virts EL et al. Hum Mol Genet 2015; 24 (18):5093-108 AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Application : WB
Reactivity : Human
Fu H et al. Nat Commun 2015; 6:6746 The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.
Application : WB
Reactivity : Human
Yu HW et al. J Cell Mol Med 2015; 19 (5):934-47 β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.
Application : WB
Reactivity : Human
Yang M et al. J Lipid Res 2014; 55 (2):226-38 Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake.
Application : EMSA
Reactivity : Human
Corradini E et al. Mol Cell Proteomics 2014; 13 (8):2004-16 Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse.
Application : WB
Reactivity : Mouse
Fragkouli A et al. Front Cell Neurosci 2014; 8:182 miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway.
Application : WB
Reactivity : Mouse
Jullienne A et al. J Cereb Blood Flow Metab 2014; 34 (10):1637-45 Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.
Application : WB
Reactivity : Rat
Hutt DM et al. PLoS One 2014; 9 (8):e106224 The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition.
Application : WB
Reactivity : Human
Yang SH et al. Biomed Res Int 2014; 2014:312847 Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.
Application : WB
Reactivity : Rat
Ma F et al. Nat Commun 2014; 5:5494 retinoid x receptor α attenuates host antiviral response by suppressing type i *.
Application : WB
Reactivity : Mouse
Chaudhury I et al. Mol Cell Biol 2014; 34 (21):3939-54 FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.
Yeo JE et al. Hum Mol Genet 2014; 23 (14):3695-705 CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Huang IH et al. J Cell Sci. 2014; 127 (Pt 19):4186-200 GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment.
Application : WB
Reactivity : Human
Kang CC et al. Anal Chem 2014; 86 (20):10429-36 Single-cell Western blotting after whole-cell imaging to assess cancer chemotherapeutic response.
Application : WB
Reactivity : Human
Dvoriantchikova G et al. Eur J Neurosci 2014; Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways.
Application : WB
Reactivity : Mouse
Lin CH et al. Int Immunopharmacol 2014; The effect of sesamin on airway fibrosis in vitro and in vivo.
Application : WB
Reactivity : Human, Mouse
James AW et al. Tissue Eng Part A 2014; Lentiviral delivery of PPARγ shRNA Alters the Balance of Osteogenesis and Adipogenesis, Improving Bone Microarchitecture.
Application : WB
Reactivity : Mouse
Kohsaka S et al. Nat Genet 2014; 46 (6):595-600 A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Application : WB
Reactivity : Human
Grabiner BC et al. Cancer Discov 2014; A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity.
Application : WB
Reactivity : Human
Johnson MA et al. PLoS One 2014; 9 (4):e93597 Amino Acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
Application : WB
Reactivity : Human
Colbert LE et al. Cancer Res 2014; CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer.
Application : WB
Reactivity : Human
Al-Sawaf O et al. Sci Rep 2014; 4:3625 Nrf2 protects against TWEAK-mediated skeletal muscle wasting.
Application : WB
Reactivity : Mouse
Morcavallo A et al. Matrix Biol 2014; decorin differentially modulates the activity of * receptor isoform a ligands.
Application : WB
Liu SH et al. Biochem Pharmacol 2014; 87 (2):229-42 Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.
Application : WB
Reactivity : Human
Lin W et al. EMBO J 2013; 32 (10):1425-39 Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Application : WB
Reactivity : Human
Ruisu K et al. PLoS One 2013; 8 (8):e74031 Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.
Application : WB
Reactivity : Mouse
Chang YC et al. EMBO Mol Med 2013; 5 (8):1165-79 Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Application : WB
Reactivity : Mouse
Lam T et al. PLoS One 2013; 8 (11):e80414 Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
Application : WB
Reactivity : Human
Zhang K et al. J Neurosci 2013; 33 (17):7451-62 Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling.
Application : WB
Reactivity : Rat
Son J et al. Genes Dev 2013; 27 (24):2663-77 Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin.
Application : WB
Reactivity : Mouse
Angulo-Rojo C et al. ASN Neuro 2013; 5 (5):e00130 Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA.
Application : WB
Reactivity : Rat
Hall WA et al. Oncogene 2013; Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
Application : WB
Reactivity : Human
Krieger M et al. Brain 2013; 136 (Pt 12):3634-44 SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome.
Application : WB
Reactivity : Human
Cho YW et al. PLoS One 2013; 8 (6):e66514 Zfp423 binds autoregulatory sites in p19 cell culture model.
Application : WB
Reactivity : Human
Chaudhury I et al. Nucleic Acids Res 2013; 41 (13):6444-59 FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Application : WB
Reactivity : Human
Bennett BJ et al. Cell Metab 2013; 17 (1):49-60 Trimethylamine-N-oxide, a * associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Application : WB
Reactivity : Mouse
Yang Y et al. Nucleic Acids Res 2013; 41 (4):2296-312 Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
Application : WB
Reactivity : Human
Sun Y et al. J Biol Chem 2012; 287 (48):40652-60 Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy.
Lim ST et al. J Cell Biol 2012; 197 (7):907-19 Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Application : WB
Reactivity : Mouse
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