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GDF8 / Myostatin antibody

Anti-GDF8 / Myostatin antibody used in Western Blot (WB). GTX32624
Anti-GDF8 / Myostatin antibody used in IHC (Paraffin sections) (IHC-P). GTX32624

Cat. No. GTX32624

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all GDF8 / Myostatin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

43 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 267-375 of human MSTN (NP_005250.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887670

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

myostatin , GDF8 , MSLHP

Cellular Localization

Secreted

Background

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-GDF8 / Myostatin antibody used in Western Blot (WB). GTX32624

GTX32624 WB Image

WB analysis of various sample lysates using GTX32624 GDF8 / Myostatin antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-GDF8 / Myostatin antibody used in IHC (Paraffin sections) (IHC-P). GTX32624

GTX32624 IHC-P Image

IHC-P analysis of mouse lung tissue using GTX32624 GDF8 / Myostatin antibody.
Dilution : 1:100

REFERENCE

Application Reference

Kang MJ et al. J Cachexia Sarcopenia Muscle 2021;
Chen MC et al. PLoS One 2015; 10 (11) : e0143594 Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1.
Application : WB
Reactivity : Mouse
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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399