GeneTex
United States (US)

GLCNE antibody

Anti-GLCNE antibody used in Western Blot (WB). GTX33966

Cat No. GTX33966

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ELISA, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ELISA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

79 kDa. ( Note )

Specificity/Sensitivity

GLCNE Polyclonal Antibody detects endogenous levels of GLCNE protein.
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthesized peptide derived from the C-terminal region of human GLCNE at AA range: 570-650.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Glucosamine (Udp-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase,Dmrv,Glcne,Ibm2,Nm,Uae1,Gne

Background

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-GLCNE antibody used in Western Blot (WB). GTX33966

GTX33966 WB Image

Western Blot (WB) analysis of 3T3 cells using GLCNE Polyclonal Antibody.

Package List Price ($)
$ 319