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GLCNE antibody

Anti-GLCNE antibody used in IHC (Paraffin sections) (IHC-P). GTX65984
Anti-GLCNE antibody used in Western Blot (WB). GTX65984
Anti-GLCNE antibody used in IHC (Paraffin sections) (IHC-P). GTX65984

Cat. No. GTX65984

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all GLCNE products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

79 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant funsion protein containing a sequence corresponding to amino acids 1-150 of human GNE (NP_001121699.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase , DMRV , GLCNE , IBM2 , NM , Uae1

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-GLCNE antibody used in IHC (Paraffin sections) (IHC-P). GTX65984

GTX65984 IHC-P Image

IHC-P analysis of human esophagus tissue using GTX65984 GLCNE antibody.
Dilution : 1:100

Anti-GLCNE antibody used in Western Blot (WB). GTX65984

GTX65984 WB Image

WB analysis of various sample lysates using GTX65984 GLCNE antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-GLCNE antibody used in IHC (Paraffin sections) (IHC-P). GTX65984

GTX65984 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX65984 GLCNE antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399