APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
5 - 10 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rat, Sheep, Bovine, Chicken, Elephant, Gibbon, Gorilla, Marmoset, Opossum, Panda, Turkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human GLP1R.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
glucagon like peptide 1 receptor , GLP1 , GLP1R
Cellular Localization
Cell membrane
Background
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Database
Research Area
DATA IMAGES
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GTX44806 IHC-P Image
IHC-P analysis of human pancreas tissue using GTX44806 GLP1R antibody.
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GTX44806 IHC-P Image
IHC-P analysis of human cortex tissue using GTX44806 GLP1R antibody.
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GTX44806 IHC-P Image
IHC-P analysis of human heart tissue using GTX44806 GLP1R antibody.
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REFERENCE
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REVIEW
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