*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
28 , 46, 68, 111 kDa. ( Note
A431 , Mouse brain
Rat, Bovine, Dog, Pig, Xenopus laevis, Xenopus tropicalis(>80% identity)
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.78mg/ml(Please refer to the vial label for the specific concentration.)
Recombinant protein encompassing a sequence within the C-terminus region of human GNAS. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
AHO antibody, C20orf45 antibody, GNAS1 antibody, GPSA antibody, GSA antibody, GSP antibody, MGC33735 antibody, NESP antibody, PHP1A antibody, PHP1B antibody, PHP1C antibody, POH antibody, GNAS antibody, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 antibody, protein ALEX antibody, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas antibody, adenylate cyclase-stimulating G alpha protein antibody, neuroendocrine secretory protein antibody, extra large alphas protein antibody, guanine nucleotide regulatory protein antibody, secretogranin VI antibody, alternative gene product encoded by XL-exon antibody, GNAS complex locus antibody
Cell membrane; Peripheral membrane protein , Cell projection , ruffle , Cell membrane , Cell projection , ruffle
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]