APPLICATION
Application Note
This antibody, used at a concentration of 10-20μg/mL will allow visualization of NP 40 solubized normal human platelets
Product Note
Under reducing conditions, this antibody will bind against the human platelet membrane glycoproteins IIb and/or IIIa, which have molecular weights of ~130,000 (IIb) and 115,000 (IIIa).
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
109 human platelets suspension. The supernatant fluid from positive clones was screened by ELISA coated with washed platelets
Purification
Protein G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD61 , GP3A , HPA3 , Integrin beta3 antibody , Integrin beta 3 antibody , Integrin alpha2b , Integrin alpha 2b , GPIIIa , CD41b , GP IIb/IIIa , GPIIIb , GTA , CD41 , GP2B , GPIIb
Background
The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.
Research Area
REFERENCE
There are currently no references for GP IIb/IIIa antibody [237] (GTX20662). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for GP IIb/IIIa antibody [237] (GTX20662). Be the first to share your experience with this product.