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GP2 antibody [GP2/1712]

Anti-GP2 antibody [GP2/1712] used in IHC (Paraffin sections) (IHC-P). GTX34766

Cat No. GTX34766

Host

Mouse

Clonality

Monoclonal

Clone Name

GP2/1712

Isotype

IgG

Application

ICC/IF, IHC-P

Reactivity

Human
Package
100 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 0.5-1ug/ml
IHC-P 1-2ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

59 kDa. ( Note )

Specificity/Sensitivity

GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human GP2 protein fragment (aa35-179) (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Glycoprotein 2 , Zap75 , Gp2

Background

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Database

DATA IMAGES

Anti-GP2 antibody [GP2/1712] used in IHC (Paraffin sections) (IHC-P). GTX34766

GTX34766 IHC-P Image

Formalin-fixed, paraffin-embedded human Pancreas stained with GP2 Monoclonal Antibody (GP2/1712).

REFERENCE

There are currently no references for GP2 antibody [GP2/1712] (GTX34766). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for GP2 antibody [GP2/1712] (GTX34766). Be the first to share your experience with this product.
Package List Price ($)
$ 429