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GPR149 antibody

Anti-GPR149 antibody used in IHC (Paraffin sections) (IHC-P). GTX71857

Cat No. GTX71857

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human
Package
25 μg ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 7 - 18 μg/ml
Not tested in other applications.

Calculated MW

81 kDa. ( Note )

Predict Reactivity

Rabbit, Bovine, Pig, Monkey, Bat, Elephant, Gibbon, Gorilla, Marmoset(>80% identity)
PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 15 amino acid peptide from N-terminal extracellular domain of human GPR149.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

G protein-coupled receptor 149 , IEDA , PGR10 , R35

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

Database

Research Area

DATA IMAGES
Anti-GPR149 antibody used in IHC (Paraffin sections) (IHC-P). GTX71857

GTX71857 IHC-P Image

IHC-P analysis of human testis tissue (seminiferous epithelium) using GTX71857 GPR149 antibody.
Antigen retrival : Heat-induced antigen retrieval

REFERENCE
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REVIEW
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Package List Price ($)
$ 319