APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 41 - 62 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Mouse, Rat, Zebrafish, Rabbit, Bovine, Dog, Hamster, Chicken, Monkey, Bat, Elephant, Gorilla, Horse, Marmoset, Opossum, Panda, Pufferfish, Turkey, Xenopus, Platypus, Sea bass, Stickleback, Zebra finch(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 16 amino acid peptide from 1st extracellular domain of human GPR30.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
G protein-coupled estrogen receptor 1 , CEPR , CMKRL2 , DRY12 , FEG1 , G proteincoupled estrogen receptor 1 , GPCRBr , GPER , GPER1 , GPR30 , LERGU , LERGU2 , LyGPR , mER
Cellular Localization
Nucleus,Cytoplasm,Perinuclear region,Cytoskeleton,Cell membrane,Basolateral cell membrane,Cytoplasmic vesicle membrane,Early endosome,Recycling endosome,Golgi apparatus membrane,Golgi apparatus,trans-Golgi network,Endoplasmic reticulum membrane,Cell projection,Dendrite,Dendritic spine membrane,Axon,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Mitochondrion membrane
Background
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
Database
Research Area
DATA IMAGES
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GTX12564 IHC-P Image
IHC-P analysis of human lung, non-small cell carcinoma tissue using GTX12564 GPR30 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX12564 IHC-P Image
IHC-P analysis of human colon, carcinoma tissue using GTX12564 GPR30 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX12564 IHC-P Image
IHC-P analysis of human colon, carcinoma tissue using GTX12564 GPR30 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX12564 IHC-P Image
IHC-P analysis of lung, non small cell carcinoma tissue using GTX12564 GPR30 antibody.
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GTX12564 IHC-P Image
IHC-P analysis of human breast carcinoma tissue using GTX12564 GPR30 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX12564 IHC-P Image
IHC-P analysis of prostate, adenocarcinoma tissue using GTX12564 GPR30 antibody.
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REFERENCE
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REVIEW
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