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GRB10 antibody

Anti-GRB10 antibody used in Western Blot (WB). GTX31469
Anti-GRB10 antibody used in IHC (Paraffin sections) (IHC-P). GTX31469

Cat. No. GTX31469

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all GRB10 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 20 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

67 kDa. ( Note )

Positive Control

SK-N-SH Cell Lysate(GTX23956)

Product Note

At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10.The immunogen is located within amino acids 440 - 490 of GRB10.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

growth factor receptor bound protein 10 , GRB-IR , Grb-10 , IRBP , MEG1 , RSS

Cellular Localization

Cytoplasm

Background

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Database

Research Area

DATA IMAGES

Anti-GRB10 antibody used in Western Blot (WB). GTX31469

GTX31469 WB Image

WB analysis of SK-N-SH cell lysate using GTX31469 GRB10 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-GRB10 antibody used in IHC (Paraffin sections) (IHC-P). GTX31469

GTX31469 IHC-P Image

IHC-P analysis of rat brain tissue using GTX31469 GRB10 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399