APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)
Product Note
This Grik5 antibody does not cross-react with Grik4.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Grik5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Grik5.The immunogen is located within the last 50 amino acids of Grik5.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
glutamate ionotropic receptor kainate type subunit 5 , EAA2 , GRIK2 , GluK5 , KA2
Cellular Localization
Cell membrane; Multi-pass membrane protein
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1- mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface. This Grik5 antibody does not cross-react with Grik4.
Database
Research Area
DATA IMAGES
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GTX85043 IHC-P Image
IHC-P analysis of human brain tissue using GTX85043 GRIK5 antibody.
Working concentration : 2.5 μg/ml
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GTX85043 WB Image
WB analysis of human brain tissue lysate using GTX85043 GRIK5 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml
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GTX85043 IHC-P Image
IHC-P analysis of human brain tissue using GTX85043 GRIK5 antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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