Geminin antibody [EM6]

Name: Geminin antibody [EM6]
Brand: GeneTex
SKU: GTX01909
Price: 569.00 USD
Rating: 4 (1 reviews)

Anti-Geminin antibody [EM6] used in IHC (Paraffin sections) (IHC-P). GTX01909

Cat. No. GTX01909

Host	Mouse
Clonality	Monoclonal
Clone Name	EM6
Isotype	IgG2a
Application	WB, IHC-P
Reactivity	Human
Package	500 μl ($569)

See all Geminin products

Datasheet

View product citations for antibody GTX01909 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	Assay dependent
IHC-P	1:40
Note : IHC-P The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections.

Not tested in other applications.

Calculated MW

24 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

A prokaryotic recombinant protein containing amino acids 5–209 of the mature protein.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

geminin DNA replication inhibitor , Gem , MGORS6

Cellular Localization

Cytoplasm , Nucleus

Background

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Database

Gene ID: 51053 GMNN
UniProt: O75496 GMNN

Research Area

DATA IMAGES

GTX01909 IHC-P Image

IHC-P analysis of human chronic lymphocytic leukemia tissue using GTX01909 Geminin antibody [EM6]. Note intense nuclear staining of proliferating neoplastic cells.

REFERENCE

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REVIEW