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Ghrelin preproprotein antibody, C-term

Anti-Ghrelin preproprotein antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89489
Anti-Ghrelin preproprotein antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89489

Cat No. GTX89489

Host

Goat

Clonality

Polyclonal

Isotype

IgG

Application

ICC/IF, IHC-P

Reactivity

Human, Rat
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-P 2μg/ml

Note :

IHC-P
Human Placenta shows staining of trophoblast cytoplasm.

Not tested in other applications.

Calculated MW

13 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX89489-PEP).

Product Note

This antibody is expected to recognise all reported isoforms.

PROPERTIES

Form

Liquid

Buffer

TBS pH7.3, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-QDILWEEAKEAPADK, from the C Terminus of the protein sequence according to NP_057446.1; NP_001128413.1; NP_001128416.1; NP_001128417.1; NP_001128418.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ghrelin and obestatin prepropeptide , MTLRP

Cellular Localization

Secreted

Background

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]

Database

Research Area

DATA IMAGES

Anti-Ghrelin preproprotein antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89489

GTX89489 IHC-P Image

IHC-P analysis of human placenta using GTX89489 Ghrelin preproprotein antibody, C-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 2μg/ml

Anti-Ghrelin preproprotein antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX89489

GTX89489 IHC-P Image

IHC-P analysis of human colon using GTX89489 Ghrelin preproprotein antibody, C-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 2μg/ml

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 379