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GluR2 antibody

Anti-GluR2 antibody used in Western Blot (WB). GTX00632
Anti-GluR2 antibody used in IHC (Frozen sections) (IHC-Fr). GTX00632
Anti-GluR2 antibody used in Immunoprecipitation (IP). GTX00632

Cat No. GTX00632

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-Fr, IP, LCI

Reactivity

Mouse, Rat
Package
50 μl ($389)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
LCI Assay dependent
Not tested in other applications.

Calculated MW

99 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 1% BSA, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.6 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide NVGNINNDKKDETYR(C), corresponding to amino acid residues 179-193 of rat GluR2 (Accession P19491). Extracellular, N-terminus.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

glutamate ionotropic receptor AMPA type subunit 2 , GluA2 , GluR-K2 , GluR2 , gluR-B

Cellular Localization

Cell membrane,Endoplasmic reticulum membrane

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-GluR2 antibody used in Western Blot (WB). GTX00632

GTX00632 WB Image

WB analysis of rat brain membrance lysates using GTX00632 GluR2 antibody.
Lane 1 : Primary antibody
Lane 2 : Primary antibody preincubated with the negative control antigen

Anti-GluR2 antibody used in IHC (Frozen sections) (IHC-Fr). GTX00632

GTX00632 IHC-Fr Image

IHC-Fr analysis of rat cerebellum tissue using GTX00632 GluR2 antibody. Note that some GluA2 positive fibers (horizontal arrow) that are probable Bergmann glial processes do not stain for GluA2. _x000D_
Panel A : Co-localization of GluA2 (green) and calbindin D28-K (red) in Purkinje cell dendrites (vertical arrow). _x000D_
Panel B : Calbindin D28-K_x000D_
Panel C : GTX00632_x000D_
Panel D : The molecular and Purkinje layer (blue).

Anti-GluR2 antibody used in Immunoprecipitation (IP). GTX00632

GTX00632 IP Image

IP analysis of rat brain lysates using GTX00632 GluR2 antibody. Black arrow indicates the GluR2 protein while the red arrow shows the IgG heavy chain.
Lane 1 : Primary antibody
Lane 2 : Pre-immune rabbit serum
Lane 3 : Input

REFERENCE

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REVIEW

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