APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1/1,000 |
| 1/1,000 |
Not tested in other applications.
Calculated MW
Product Note
This antibody recognizes human GR, binding to an epitope between amino acids 167-176 and is therefore expected to bind all described isoforms.
PROPERTIES
Form
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
26 amino acid peptide corresponding to residues 150-176 of human GCR linked to human thyroglobulin.
Purification
Protein G purified
From tissue culture supernatant
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
nuclear receptor subfamily 3 group C member 1 , GCCR , GCR , GCRST , GR , GRL
Cellular Localization
Nucleus , Mitochondrion , Cytoplasm
Background
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Database
Research Area
REFERENCE
There are currently no references for Glucocorticoid Receptor antibody [8E9] (GTX11379). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Glucocorticoid Receptor antibody [8E9] (GTX11379). Be the first to share your experience with this product.
